Saturday, February 26, 2011
Klinefelter's Syndrome
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Arif Siregar |
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The clinical features of Klinefelter's syndrome are found only in men and is usually detected at puberty, namely sterility, testicular atrophy, hyalinization of seminiferous tubules, and usually gynecomastia. In 80% of cases found in the cells that has 47 types of sex chromosomes XXY, and one sex chromatin body / Barr body, which was formed by compaction of sex chromosomes which have inactivation. Barr bodies are also present in normal women. Its incidence is approximately 1 in 500 men. Nondisjunction of homologous XX is the most common cause. Sometimes patients with Klinefelter's syndrome have 48 chromosomes, namely 44 autosomal and 4 sex chromosomes (XXXY). Although mental retardation is not a general description of this syndrome, the more there is the X chromosome the greater the likelihood of mental disorders.
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